BARRIO LAB

Barrio Lab Family 


Jorge R. Barrio, PhD.  

Born in Buenos Aires, Argentina, Dr. Jorge R. Barrio received his BS (Biochemistry) and PhD (Biochemistry) at the University of Buenos Aires. He met his sweetheart Maria at the same University and later married her more than 40 years ago. Together they have four children – Juan Carlos, Lorena, Adrian and Andrea – and six grandchildren. In 1970, both moved to the University of Illinois at Urbana-Champaign - working in the Department of Chemistry under the mentorship of Professors Nelson J. Leonard and Gregorio Weber- where he developed the first specific fluorescent probes for nucleosides and nucleotides and obtained his second PhD (Chemistry). In 1979, he received a tenured appointment at the UCLA School of Medicine – in the earliest stages of development of positron emission tomography, an in vivo technique pioneered by Dr Michael E. Phelps. In the last 30 years Dr. Barrio developed new synthesis approaches for positron emitting labeled probes, automated modules for syntheses now widely used commercially and molecular imaging probe approaches to investigate the biochemical mechanisms of neurodegenerative diseases. These include Parkinson’s disease, Alzheimer’s disease and prion diseases. In addition, he has developed  tools for in vivo monitoring of gene expression in animals and humans.

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Jorge R. Barrio, PhD
Distinguished Professor
UCLA Pharmacology
BOX 956948, B2-086A CHS
Los Angeles, CA 90095-6948
310-825-4167
jbarrio@mednet.ucla.edu

Vladimir Kepe, PhD.  

Born in Murska Sobota, Slovenia, Dr. Vladimir Kepe received his BS in chemistry in 1990 and his PhD (Chemistry) in 1996 from University of Ljubljana, Ljubljana, Slovenia. He moved to Los Angeles in 1997 to the Barrio lab at UCLA as a post-doctoral fellow. Since then he has worked on a multitude of projects in organic synthetic chemistry, radiosynthesis, determination of biodistribution and dosimetry for new PET tracers, microPET imaging experiments, human PET imaging experiments and PET imaging data analysis. Since 2003 his focus has been on in vivo imaging of pathological brain protein aggregates with [F-18]FDDNP PET in sporadic and familial Alzheimer’s disease, prion diseases, Down’s syndrome, Parkinson’s disease, and Huntington’s disease. His more recent interests include PET imaging of neuroreceptors (serotonin 1A), sodium dependent glucose transporters (SGLTs) and estrogen sulfortransferase in neurodegenerative disorders and related conditions.

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Vladimir Kepe, PhD
Researcher
UCLA Pharmacology
BOX 956948, B2-050 CHS
Los Angeles, CA 90095-6948
310-267-2637
vkepe@mednet.ucla.edu

Jie Liu, PhD

Born in Beijing, China Jie Liu, PhD graduated from the Pharmacy College in Beijing Medical School in the spring of 1982. She earned a Master's of Science after doing research on organic synthesis of natural products in the Chinese Academy of Medicinal Sciences. Jie, her husband and their only child moved to Belgium in 1987, where she earned her PhD in Pharmaceutical Sciences from the Catholic University of Leuven in two years. She specialized in the synthesis of anti-HIV nucleosides. They also lived in France for several years. During her time in France and Belgium, Jie did postdoctoral research in the CNRS (Rega Institute) on the synthesis of biologically active compounds. After joining Dr. Barrio’s research lab at UCLA as a post-doc in 1997, Dr. Liu's family moved to the United States. Since 2001, Jie has been involved in the radiosynthesis of F-18 labeled PET tracers for animal and clinical researches conducted by the group and collaborators. Currently, Jie is an Assistant Researcher responsible for the synthetic and analytical work for PET tracers and their chemical precursors. She enjoys the challenges in new PET tracer development.

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Jie Liu, PhD
Associate Researcher
UCLA Pharmacology
BOX 956948, B2-050 CHS
Los Angeles, CA 90095-6948
310-825-5886
jliu@mednet.ucla.edu

Claudio Scafoglio, MD, PhD  

Born in Napoli, Italy, Dr. Claudio Scafoglio received his Medical Degree in 2002 and his PhD in Medical and Surgical Oncology in 2006 from the Seconda Università degli Studi di Napoli, where he combined the basic science work on gene expression profiling in hormone-dependent breast cancer cell lines with the clinical activity on cancer patients. From 2005 to 2011 he worked, first as a graduate student, then as a post-doctoral scholar, at University of California, San Diego, on different projects related to the regulation of gene expression, with particular focus on transcriptional repression and its role in the induction of programmed cell death in response to DNA damage. Claudio joined Dr. Barrio’s lab in 2012, to study the activity and biological significance of sodium-dependent glucose transporters in cancer.

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Claudio Scafoglio, MD, PhD
UCLA Pharmacology
BOX 951735, B2-034 CHS
Los Angeles, CA 90095-1735
310-825-4530
CScafoglio@mednet.ucla.edu  

Matt John Silverman

Born and raised in Mountain View, California, Matt Silverman received his BS in chemical engineering at UCLA in 2006, and an MS in chemical engineering in 2010, working on manipulating metabolic pathways in bacteria to produce various compounds in bacteria for use as biofuels and other products.  After completing his MS, Matt did a couple rotations in labs in the UCLA pharmacology department looking for a chance to do a PhD project studying cancer, and has since joined Dr. Barrio’s lab studying SGLT expression in various cancers.  Matt is also involved in a variety of campus groups at UCLA, ranging from helping develop resources for entrepreneurs in the Technical Entrepreneurial Community to serving on the leadership team of Chi Alpha Christian Fellowship

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Matt John Silverman
UCLA Pharmacology
BOX 951735, B2-034 CHS
Los Angeles, CA 90095-1735
msilverm@ucla.edu 


Jason Wu 

My name is Jason Wu. I am an upcoming third year majoring in Biochemistry in UCLA.  I immigrated to San Francisco when I was 10 years old from Guangzhou, China. Ever since then, I have been interested in the field of science. After the recent finish of the whole series of Organic Chemistry in UCLA, I was impressed by its significance in science and medicine. Therefore, I decided to look for a research laboratory that applies organic chemistry as one of the techniques to approach a variety of neurodegenerative diseases.  As a result, I joined Dr. Barrio’s Lab in the summer of 2012 as a CARE SEM Scholar, working on a project involved with the validation of FDDNP PET in neurodegenerative diseases. In the future, I would like to learn more about PET Imaging and have a career in the field of science and medicine.

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Jason Wu
UCLA Pharmacology
BOX 951735, B2-034 CHS
Los Angeles, CA 90095-1735
jason.wu@ucla.edu